
5-Amino 1MQ 50mg
$119.99
Small-molecule inhibitor of nicotinamide N-methyltransferase, studied in NAD+ salvage and methyl-pool metabolism. Research use only.
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Pairs with every vialISLA-H20 10mLBacteriostatic water for reconstitution$19.99Identity
5-Amino-1MQ is 5-amino-1-methylquinolinium, a cell-permeable small-molecule quinolinium salt. It is not a peptide and is supplied as a dry powder.
Molecular target
Nicotinamide N-methyltransferase, a cytosolic enzyme that transfers a methyl group from S-adenosylmethionine to nicotinamide, producing 1-methylnicotinamide. NNMT is highly expressed in adipose tissue and liver.
Signalling pathway
Inhibiting the enzyme has two linked consequences that the literature examines separately. Nicotinamide that would otherwise be methylated and excreted remains available to the NAD+ salvage pathway, and the SAM methyl pool is spared for histone and DNA methylation reactions. Published mouse work using adipocyte NNMT knockdown reported changes in fat mass without a change in food intake.
Research context
3T3-L1 adipocyte culture and diet-induced-obese mouse models. Preclinical only.
Specification
- Form: powder, sealed vial
- Purity: verified by high-performance liquid chromatography with mass spectrometric confirmation
- Analysis: third-party tested, full report published against the batch number on the vial
- Storage: 2-8 °C
Handling: See our step-by-step reconstitution protocol, and our guide to bacteriostatic water vs sterile water for choosing a diluent.
For laboratory research use only. Not for human or veterinary use.
Important
- ISLA-H20 sold separately
- Syringes not included
- Supplied as lyophilised powder
- Third-party tested, every batch
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All products are supplied strictly for in-vitro laboratory research purposes only. Not for human consumption, medical, or veterinary use. Isla Longevity does not condone the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution and are at least 21 years old.
? Details
Intended Use: Supplied for laboratory research purposes only. All peptides require reconstitution with ISLA-H20, sold separately.
Form: Lyophilised (freeze-dried) powder in a sealed sterile vial.
Storage: Store the vial in a cool, dry place away from direct light. Once reconstituted, keep refrigerated at 2–8°C and use within the recommended timeframe.
Solubility: Reconstitute with ISLA-H20. Avoid repeated freeze–thaw cycles to preserve integrity.
Testing: Every batch is independently analysed by Freedom Diagnostics, with certificates of analysis published openly.
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