Sermorelin 10mg

Identity

Sermorelin is GHRH(1-29) amide: the first 29 residues of the 44-residue human growth hormone-releasing hormone, and the shortest fragment that retains the full biological activity of the parent hormone.

Molecular target

The GHRH receptor, a class B Gs-coupled receptor found on anterior pituitary somatotrophs.

Signalling pathway

Receptor occupancy activates adenylyl cyclase, raising cyclic AMP and activating protein kinase A, which phosphorylates CREB. This drives both immediate release of stored growth hormone and Pit-1-dependent transcription of the growth hormone gene. Because the action is upstream at the pituitary, output in these models remains subject to somatostatin negative feedback, which is the principal design contrast with administering growth hormone directly.

Research context

Pituitary cell culture and rodent hypothalamic-pituitary-somatotropic axis models. Plasma half-life is short, on the order of minutes, which constrains study design.

Specification

• Form: lyophilised powder, sealed vial
• Purity: verified by high-performance liquid chromatography with mass spectrometric confirmation
• Analysis: third-party tested, full report published against the batch number on the vial
• Storage: 2-8 °C

Handling: See our step-by-step reconstitution protocol, and our guide to bacteriostatic water vs sterile water for choosing a diluent.

For laboratory research use only. Not for human or veterinary use.