REM Spray

Format

REM Spray is supplied as a ready-to-use buffered aqueous solution in a 10 mL spray bottle, so no reconstitution step is needed. Contents: 10 mg Pinealon, 10 mg Epitalon and 10 mg DSIP per 10 mL.

Components

Pinealon. Pinealon is the tripeptide Glu-Asp-Arg (EDR), composed of L-glutamic acid, L-aspartic acid and L-arginine. Within the Khavinson series it is the peptide assigned to brain and pineal tissue. It is a separate compound from Epithalon (Ala-Glu-Asp-Gly), with which it is frequently confused in secondary sources.

Epitalon. Epitalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, derived from research on pineal-gland extracts. It is a short, fully synthetic sequence rather than an extracted material.

DSIP. Delta sleep-inducing peptide is the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, isolated in 1977 from the cerebral venous blood of rabbits during electrically induced slow-wave sleep and named for the EEG band it was associated with.

Research context

Each component has its own independent literature, and the combination is studied as a system rather than as a single pharmacology. For the mechanism and research background of each compound, see Pinealon, Epitalon, DSIP.

Specification

• Form: ready-to-use buffered aqueous solution, 10 mL spray bottle
• Contents: 10 mg Pinealon, 10 mg Epitalon and 10 mg DSIP per 10 mL
• Purity: each compound verified by high-performance liquid chromatography with mass spectrometric confirmation
• Analysis: third-party tested
• Storage: 2-8 °C, keep sealed and upright

For laboratory research use only. Not for human or veterinary use.