VIP 10mg

Identity

Vasoactive intestinal peptide is a 28-residue neuropeptide of the secretin and glucagon superfamily, distributed across enteric, central and peripheral neurons and released from a subset of immune cells.

Molecular target

VPAC1 and VPAC2, class B Gs-coupled receptors, with lower-affinity binding at PAC1. The two VPAC subtypes differ in tissue distribution, which is the usual basis for separating peripheral from central effects in a study design.

Signalling pathway

Both VPAC receptors signal through adenylyl cyclase to cyclic AMP and protein kinase A. Three separate literatures draw on this: smooth-muscle relaxation in gut and vascular preparations, circadian pacemaking in the suprachiasmatic nucleus where VPAC2 is required for network synchrony, and immunomodulation, where VIP has been studied for shifting macrophage and T-cell populations toward a regulatory phenotype.

Research context

Enteric and vascular tissue preparations, suprachiasmatic nucleus slice recording, and murine autoimmunity models.

Specification

• Form: lyophilised powder, sealed vial
• Purity: verified by high-performance liquid chromatography with mass spectrometric confirmation
• Analysis: third-party tested, full report published against the batch number on the vial
• Storage: 2-8 °C

Handling: See our step-by-step reconstitution protocol, and our guide to bacteriostatic water vs sterile water for choosing a diluent.

For laboratory research use only. Not for human or veterinary use.