Thymosin Alpha-1 10mg

Identity

Thymosin alpha-1 is an N-terminally acetylated 28-residue peptide corresponding to the first 28 residues of prothymosin alpha. It was originally isolated from thymosin fraction 5 of bovine thymus, and unlike the crude thymic extracts of the same era it is a single defined sequence.

Molecular target

Toll-like receptors, principally TLR2 and TLR9 on dendritic cells and monocytes. No single high-affinity receptor has been identified.

Signalling pathway

Toll-like receptor engagement recruits MyD88 and activates NF-kappaB. Published work has examined the consequences for dendritic cell maturation, IL-12 and interferon-gamma production and Th1 polarisation, and separately for thymocyte differentiation and natural killer cell activity.

Research context

Human peripheral blood mononuclear cell and dendritic cell culture, and murine immunology models. Among the more heavily published peptides in this catalogue.

Specification

• Form: lyophilised powder, sealed vial
• Purity: verified by high-performance liquid chromatography with mass spectrometric confirmation
• Analysis: third-party tested, full report published against the batch number on the vial
• Storage: 2-8 °C

Handling: See our step-by-step reconstitution protocol, and our guide to bacteriostatic water vs sterile water for choosing a diluent.

For laboratory research use only. Not for human or veterinary use.