Dihexa Spray

Format

Dihexa Spray is supplied as a ready-to-use buffered aqueous solution in a 10 mL spray bottle, so no reconstitution step is needed. Contents: 10 mg Dihexa per 10 mL.

Identity

Dihexa is N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, a synthetic analogue of angiotensin IV developed at Washington State University. It is the only compound in this range designed from the outset for oral stability.

Molecular target

Hepatocyte growth factor and its receptor c-Met. Dihexa is described as a positive modulator: it does not activate c-Met alone but potentiates HGF-dependent signalling, reportedly at very low concentrations.

Signalling pathway

HGF/c-Met activation recruits PI3K/Akt and MAPK cascades. Published work examines consequences for dendritic spine formation and synaptogenesis in neuronal culture.

Research context

Dihexa was specifically engineered for metabolic stability and blood-brain-barrier penetration, which is why an oral capsule is a coherent format for it rather than a compromise. The literature is primarily rodent cognition models and hippocampal neuron culture from the originating group. Preclinical only; no human trial data exists.

Specification

• Form: ready-to-use buffered aqueous solution, 10 mL spray bottle
• Contents: 10 mg Dihexa per 10 mL
• Purity: each compound verified by high-performance liquid chromatography with mass spectrometric confirmation
• Analysis: third-party tested
• Storage: 2-8 °C, keep sealed and upright

For laboratory research use only. Not for human or veterinary use.